Shopping Search

This concise, lucid textbook provides a basis for understanding the function of the respiratory system and a framework for the treatment of many respiratory diseases. It was developed as a working text with problem-solving exercises for the student's use in reviewing each chapter. The writing style flows easily from one topic to another. Mathematical relationships are presented in a simple way and are clearly explained. The illustrations are carefully designed to convey ideas in an easy-to-understand format. The book's scope is comprehensive, encompassing all aspects of respiratory physiology, including pulmonary anatomy and microstructure, mechanics, gas exchange, acid-base balance and control mechanisms. Unlike many texts, this one strikes a good balance between the principles of pulmonary gas exchange (ventilation, perfusion, gas exchange efficiency) and the neural control of respiration (central and chemical mechanisms and reflexes). It emphasizes integrative aspects of respiration such as the system's response to altitude, hyperbaric environments, exercise, sleep, and the in utero and early postnatal period. The second edition has been reorganized to make the book more approachable by students, and it has been updated throughout, including many new ideas about the distribution of lung blood blow and respiratory rhythm generation.

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Data Structures Using C++ is designed to serve as a textbook for undergraduate engineering students of computer science and information technology as well as postgraduate students of computer applications. The book aims to provide a comprehensive coverage of all the topics related to data structures. The book begins with a discussion on the fundamentals of data structures and algorithms, and moves on to the concepts of linear data structures, stacks, recursion, queues, and searching and sorting. All the elements of data structures, such as linked lists, trees, graphs, hashing, heaps, and indexing, are covered in separate chapters in detail. The chapter on files explains file management and organization using C++ and the chapter on the standard template library provides detailed coverage of entities such as containers and iterators. A chapter on algorithm analysis and design is provided towards the end that discusses the various algorithmic strategies required to solve a problem effectively and efficiently. Written in a simple manner with strong pedagogy including numerous multiple choice and review questions, the book also provides programming problems at the end of every chapter.

Evolutionary science is critical to an understanding of integrated human biology and is increasingly recognized as a core underpinning discipline by medical and public health professionals. Advances in the fields of genomics, epigenetics, developmental biology and epidemiology have led to the growing realization that incorporating evolutionary thinking is essential for medicine to achieve its full potential. This is the first integrated and comprehensive textbook to explain the principles of evolutionary biology from a medical perspective and to focus on how medicine and public health might utilize evolutionary biology. It is written in a style which is accessible to a broad range of readers, whether or not they have had formal exposure to evolutionary science. Principles of Evolutionary Medicine is divided into three sections: the first provides a systematic approach to the principles of evolutionary biology as they apply to human health and disease, using examples specifically relevant to medicine. It incorporates chapters on evolutionary processes, molecular evolution, the evolution of humans, life history theory, and evolutionary-developmental biology. The second part illustrates the application of these principles to our understanding of nutrition and metabolism, reproduction, combatting infectious disease and stress, and human behaviour. The final section provides a general framework to show in practical terms how the principles of evolutionary medicine can be applied in medical practice and public health. This novel textbook provides the necessary toolkit for doctors and other health professionals, medical students and biomedical scientists, as well as anthropologists interested in human health, to gain a better understanding of the evolutionary processes underlying human health and disease.

A valuable textbook for medical students, physiotherapists, and nurses, revised and updated for the third edition. New sections are included on ions and the heart, sickle cell anaemia, thalassaemia, glucose 6-phosphate dehydrogenase deficiency, haemophilia, protection of airways, and disorders of the intestinal tract.

The medical management of infectious diseases and antimicrobial therapy can be a daunting task for health care professionals. Although expansive textbooks and online resources are available, a simplified, quick reference guide is needed for the day-to-day office and hospital clinical practice. Mayo Clinic Antimicrobial Therapy: Quick Guide, Second Edition, provides information about infectious diseases and antimicrobial therapy in a format that is readily accessible and easily applicable to the clinical environment. Highlights of this book include drug dosing recommendations for renal function and renal replacement therapies, drugs of choice for specific organisms (including bacteria, fungi, and viruses), and simplified antimicrobial and management recommendations for specific infectious syndromes.Mayo Clinic Antimicrobial Therapy: Quick Guide, Second Edition, will assist health care providers in the management of infectious diseases and in the selection of appropriate antimicrobial therapy in a time-efficient manner.