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For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book.* And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint® presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies—animations, videos, and molecular models—all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. * There is also a reference edition of Molecular Biology of the Cell, Fifth Edition (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.

Medical Physiology is a concise introductory textbook for advanced school and beginning university students. It discusses a range of medical issues that affect the way we live our lives including infectious and inherited diseases, cancer, and diseases of the respiratory system and kidneys. The functions of the immune system and the brain are studied in some detail, as are the effects on our health of ageing, diet and exercise. The text concludes by discussing recent advances in genetics and biotechnology and their impact on the treatments available for many diseases.

For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book.* And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint® presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies—animations, videos, and molecular models—all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. * There is also a reference edition of Molecular Biology of the Cell, Fifth Edition (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.

At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.

This new textbook has an international authorship and is a practical, up-to-date resource for clinicians responsible for the care of children with oncologic and malignant hematologic disease. It is specifically designed for practicing oncologists and hematologists, pediatricians with an interest in childhood cancer and trainees seeking a systematic approach to these disorders.   This new textbook has an emphasis on the visual presentation and ease of reading of contemporary and comprehensive information for children’s cancers and contains detailed tables, fact boxes and illustrations.The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sections are then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacology and the findings of clinical trials. For each area of science covered, key original references and reviews are highlighted to direct further reading.Diagnostic, biological, and therapeutic issues are integrated into each tumor-specific chapter, with evidence supporting the current rationales for risk stratification and the development of novel therapies. A final section then explores supportive care, palliative care, late effects considerations and psychosocial issues as relate to children’s cancer.

This new textbook has an international authorship and is a practical, up-to-date resource for clinicians responsible for the care of children with oncologic and malignant hematologic disease. It is specifically designed for practicing oncologists and hematologists, pediatricians with an interest in childhood cancer and trainees seeking a systematic approach to these disorders.   This new textbook has an emphasis on the visual presentation and ease of reading of contemporary and comprehensive information for children’s cancers and contains detailed tables, fact boxes and illustrations.The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sections are then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacology and the findings of clinical trials. For each area of science covered, key original references and reviews are highlighted to direct further reading.Diagnostic, biological, and therapeutic issues are integrated into each tumor-specific chapter, with evidence supporting the current rationales for risk stratification and the development of novel therapies. A final section then explores supportive care, palliative care, late effects considerations and psychosocial issues as relate to children’s cancer.

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.

Physical Activity and Health explains clearly, systematically and in detail the relationships between physical activity, health and disease, and examines the benefits of exercise in the prevention and treatment of a wide range of important conditions. Now in a fully updated and revised edition, and still the most complete and engaging textbook on this important subject, Physical Activity and Health offers a balanced examination of the very latest evidence linking levels of physical activity with disease and mortality. It offers a wide-ranging assessment of the importance of inactivity as a factor in major diseases and health conditions such as cardiovascular disease, diabetes, obesity, cancer and osteoporosis. The book is designed to help the reader evaluate the quality and significance of the scientific evidence, and includes an invaluable discussion of common study designs and the inherent difficulties of measuring physical activity. It also explores the full range of contemporary themes in the study of exercise and health, such as the hazards of exercise; exercise and the elderly; children’s health and exercise; physical activity and public health policy; and a critical appraisal of current recommendations for physical activity. Containing useful features throughout, such as chapter summaries, study tasks, guides to supplementary reading and definitions of key terms, and richly illustrated with supporting tables, figures and plates, Physical Activity and Health is an essential course text. Now supported by a companion website featuring self-test questions, PowerPoint slides for lecturers, additional learning activities and web links, this book is vital reading for degree-level students of sport and exercise science, public health, physical therapy, medicine and nursing. Visit the companion website for Physical Activity and Health at www.routledge.com/textbooks/9780415421980.

Physical Activity and Health explains clearly, systematically and in detail the relationships between physical activity, health and disease, and examines the benefits of exercise in the prevention and treatment of a wide range of important conditions. Now in a fully updated and revised edition, and still the most complete and engaging textbook on this important subject, Physical Activity and Health offers a balanced examination of the very latest evidence linking levels of physical activity with disease and mortality. It offers a wide-ranging assessment of the importance of inactivity as a factor in major diseases and health conditions such as cardiovascular disease, diabetes, obesity, cancer and osteoporosis. The book is designed to help the reader evaluate the quality and significance of the scientific evidence, and includes an invaluable discussion of common study designs and the inherent difficulties of measuring physical activity. It also explores the full range of contemporary themes in the study of exercise and health, such as the hazards of exercise; exercise and the elderly; children’s health and exercise; physical activity and public health policy; and a critical appraisal of current recommendations for physical activity. Containing useful features throughout, such as chapter summaries, study tasks, guides to supplementary reading and definitions of key terms, and richly illustrated with supporting tables, figures and plates, Physical Activity and Health is an essential course text. Now supported by a companion website featuring self-test questions, PowerPoint slides for lecturers, additional learning activities and web links, this book is vital reading for degree-level students of sport and exercise science, public health, physical therapy, medicine and nursing. Visit the companion website for Physical Activity and Health at www.routledge.com/textbooks/9780415421980.

Nutrition in Pediatrics, Third Edition, is the authoritative textbook on pediatric nutrition for pediatricians, dieticians, pediatric gastroenterologists, family practitioners, and medical students. The text thoroughly covers general principles, pathophysiology, clinical conditions, and definitive treatment. This new edition is the first book on pediatric nutrition published in the last five years and features major revisions. Expanded in the Third Edition: · the Macronutrient Requirement for Growth chapter has been expanded to three chapters to deal separately with fat, carbohydrate, and protein · chapters on Maternal Nutrition and Pregnancy Outcome and Fetal Nutrition and Imprinting · the section on Specific Disease States has been enlarged to include The Adolescent Athlete and Dietary Supplements, Nutrition and the Prevention of Cancer in Childhood, and Evaluation and Management of Obesity · the appendix has been expanded to provide a more comprehensive resource for nutritional assessment and requirements and features updated information on enteral products.

Recent advances in the understanding of the biology of colorectal cancer have radically transformed the treatment options available to clinicians, leaving textbooks written only two years ago completely out of date. This evidence-based and data-driven guide presents reviews of cutting-edge therapies for colorectal cancer, all articulated by leading experts in the field. This integrated and focused consideration of colorectal management includes reviews of cytotoxic chemotherapy, targeted biologic therapies, as well as updates on adjuvant chemotherapy for colon cancer and combined modality management of rectal cancers. Attention is also focussed on the role of potentially curative multi-modality management of liver metastases, with considerations of the role of liver resection and discussions of non-surgical ablative therapies. Supportive issues are also considered, including contributions from experts in pain management and oncology nursing. The reviews presented here are concise, up-to-date, and are organized with the treating practitioner in mind. Opening chapters outline contemporary thinking on the biology of colorectal cancer, and methods of possible prevention utilizing chemoprevention and screening. Subsequent chapters present cutting-edge uses of cytotoxic chemotherapy and review the potential for incorporating innovative biological therapy. Ample consideration is given to practical issues related to colorectal chemotherapy, specifically radiological evaluation of colorectal cancer treatment and supporting patients through chemotherapy, including pain management. The concluding chapter is devoted to the exploration of and implications of emerging new drug paradigms and their potential impact on colorectal cancer treatment. This unique text offers the practitioner a concise, authoritative reference, so that recent advancements and understanding may be digested, disseminated, and rapidly applied to the treatment of the colorectal cancer patient.

Recent advances in the understanding of the biology of colorectal cancer have radically transformed the treatment options available to clinicians, leaving textbooks written only two years ago completely out of date. This evidence-based and data-driven guide presents reviews of cutting-edge therapies for colorectal cancer, all articulated by leading experts in the field. This integrated and focused consideration of colorectal management includes reviews of cytotoxic chemotherapy, targeted biologic therapies, as well as updates on adjuvant chemotherapy for colon cancer and combined modality management of rectal cancers. Attention is also focussed on the role of potentially curative multi-modality management of liver metastases, with considerations of the role of liver resection and discussions of non-surgical ablative therapies. Supportive issues are also considered, including contributions from experts in pain management and oncology nursing. The reviews presented here are concise, up-to-date, and are organized with the treating practitioner in mind. Opening chapters outline contemporary thinking on the biology of colorectal cancer, and methods of possible prevention utilizing chemoprevention and screening. Subsequent chapters present cutting-edge uses of cytotoxic chemotherapy and review the potential for incorporating innovative biological therapy. Ample consideration is given to practical issues related to colorectal chemotherapy, specifically radiological evaluation of colorectal cancer treatment and supporting patients through chemotherapy, including pain management. The concluding chapter is devoted to the exploration of and implications of emerging new drug paradigms and their potential impact on colorectal cancer treatment. This unique text offers the practitioner a concise, authoritative reference, so that recent advancements and understanding may be digested, disseminated, and rapidly applied to the treatment of the colorectal cancer patient.